Alvocidib - CISMeF

Preferred Label : Alvocidib;

NCIt synonyms : Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; Alvocidib Freebase;

NCIt definition : The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.;

UNII : 45AD6X575G;

InChIKey : BIIVYFLTOXDAOV-YVEFUNNKSA-N;

CAS number : 146426-40-6;

Chemical formula : C21H20ClNO5;

Codes from synonyms : CDR0000630913; 31731; CDR0000045419; 24;

Details

Origin ID

C74940;

UMLS CUI

C0281603;

Currated CISMeF NLP mapping
- alvocidib [MeSH concept]
- alvocidib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- alvocidib [MeSH Supplementary Concept]
- alvocidib [MeSH concept]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Negative Regulation of G1 Phase [NCIt concept]
- Negative Regulation of G2 to M Transition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Protein Phosphorylation Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Alvocidib Hydrochloride [NCIt concept]
has_target
- Cyclin-Dependent Kinase [NCIt concept]
is_free_acid_or_base_form_of
- Alvocidib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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