" /> Alvocidib - CISMeF





Preferred Label : Alvocidib;

NCIt synonyms : Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; Alvocidib Freebase;

NCIt definition : The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.;

UNII : 45AD6X575G;

InChIKey : BIIVYFLTOXDAOV-YVEFUNNKSA-N;

CAS number : 146426-40-6;

Chemical formula : C21H20ClNO5;

Codes from synonyms : CDR0000630913; 31731; CDR0000045419; 24;

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30/05/2025


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