Cyclin-Dependent Kinase Inhibitor 2A

Preferred Label : Cyclin-Dependent Kinase Inhibitor 2A;

NCIt synonyms : CDK4I; p16-INK4; p16INK4A; Cyclin-Dependent Kinase 4 Inhibitor A; CDKN2A Protein; MTS1; p16(INK4); CDKN2A; MTS-1; Multiple Tumor Suppressor 1; Cell Cycle Negative Regulator Beta; MTS1 Protein; Cyclin-Dependent Kinase Inhibitor p12; Cyclin-Dependent Kinase Inhibitor p16; CDK4 Inhibitor; P16(INK4A); p16-INK4a; CDKN2A-p16(INK4a); Cyclin-Dependent Kinase Inhibitor 2A, Isoforms 1/2/3; Cyclin-Dependent Kinase Inhibitor-2A; CDK4 Inhibitor p16-INK4;

NCIt related terms : p16; P16 (CDKN2A);

NCIt definition : Cyclin-dependent kinase inhibitor 2A (156 aa, 17 kDa) is encoded by the human CDKN2A gene. This protein is involved in the inhibition of both cell proliferation and cell cycle progression.;

NCIt note : Cyclin-dependent kinase inhibitor 2A acts as a tumor suppressor and a negative regulator of progression through G1. It interacts with CDK4/CDK6, inhibiting both their interaction with cyclin D and the phosphorylation of RB.;

Details

Origin ID

C17786;

UMLS CUI

C4082578;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase inhibitor p16 [MeSH Descriptor]
- Cyclin-Dependent kinase inhibitor p16 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase inhibitor 2a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Head and Neck Squamous Cell Carcinoma Baseline Form [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDKN2A Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Enzyme Inhibitor Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
- Tumor Suppressor Protein [NCIt concept]
gene_product_has_gene_product_variant
- CDKN2A NP_000068.1:p.A102V [NCIt concept]
- CDKN2A NP_000068.1:p.A147T [NCIt concept]
- CDKN2A NP_000068.1:p.A148T [NCIt concept]
- CDKN2A NP_000068.1:p.A30V [NCIt concept]
- CDKN2A NP_000068.1:p.D108H [NCIt concept]
- CDKN2A NP_000068.1:p.D108Y [NCIt concept]
- CDKN2A NP_000068.1:p.H83P [NCIt concept]
- CDKN2A NP_000068.1:p.H83Y [NCIt concept]
- CDKN2A NP_000068.1:p.L130Q [NCIt concept]
- CDKN2A NP_000068.1:p.R80X [NCIt concept]
- CDKN2A NP_000068.1:p.V51D [NCIt concept]
- CDKN2A NP_000068.1:p.V51I [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- CTCF Pathway [NCIt concept]
- Cyclin Regulation of Cell Cycle Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Melanoma [NCIt concept]
- Pancreatic Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth Regulation [NCIt concept]
- Negative Regulation of G1 Phase [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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