Preferred Label : Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein
Phosphatase PTEN;
NCIt synonyms : PTEN; Mutated in Multiple Advanced Cancers 1; EC 3.1.3.48; EC 3.1.3.16; Phosphatase and Tensin Homolog; EC 3.1.3.67; PTEN Tyrosine Phosphatase; Mitochondrial Phosphatase and Tensin Protein Alpha; Mitochondrial PTENalpha; Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein
Phosphatase PTEN; Phosphatase and Tensin-Like Protein;
NCIt definition : Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein
phosphatase PTEN (403 aa, 47 kDa) is encoded by the human PTEN gene. This protein
plays a role in signaling and as both a dual-specificity phosphoprotein phosphatase
and a lipid phosphatase.;
Alternative definition : NCI-GLOSS: A protein that helps control many cell functions, including cell division
and cell death. Mutations (changes) in the gene that makes PTEN are found in many
types of cancer and other diseases. It is a type of tumor suppressor protein.;
NCIt note : PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and
tensin (which interacts with actin). PTEN inhibits insulin-induced IRS1 phosphorylation
and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced
apoptosis. PTEN blocks cell cycle progression in G1 through negative regulation of
PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing
p27, decreasing cyclin D1, and inhibiting AKT phosphorylation.;
Codes from synonyms : CDR0000653138; CDR0000653139;
Origin ID : C18181;
UMLS CUI : C1430988;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_gene_product_variant
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
