TGF-Beta Receptor Type-1

Preferred Label : TGF-Beta Receptor Type-1;

NCIt synonyms : SKR4; TGF-Beta Type I Receptor; TGF-Beta Receptor Type I; Activin Receptor-Like Kinase 5; Activin A Receptor Type II-Like Kinase 53kDa; ALK5; TGFBR1; Serine/Threonine-Protein Kinase Receptor R4; Transforming Growth Factor Beta Receptor Type I; Transforming Growth Factor Beta Receptor I; ALK-5; TbetaR-I; EC 2.7.11.30; TGFR-1; Transforming Growth Factor Beta Receptor-I; Transforming Growth Factor Beta Receptor 1; Activin A Receptor Type II-Like Protein Kinase of 53kD; Transforming Growth Factor-Beta Receptor Type I;

NCIt definition : TGF-beta receptor type-1 (503 aa, 56 kDa) is encoded by the human TGFBR1 gene. This protein plays a role in both TGF-beta-dependent signaling and serine/threonine phosphorylation.;

NCIt note : There are three TGF-beta receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif.;

Details

Origin ID

C30098;

UMLS CUI

C1686499;

Currated CISMeF NLP mapping
- Receptor, Transforming Growth Factor-beta Type I [MeSH Descriptor]
OMIM relation
- Transforming growth factor-beta receptor, type I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TGFBR1 protein, human [MeSH concept]
- TGFBR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- TGFBR1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Progression [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Galunisertib [NCIt concept]
- TGF-beta Receptor 1 Inhibitor GFH018 [NCIt concept]
- TGF-beta Receptor 1 Inhibitor PF-06952229 [NCIt concept]
- TGFbeta Inhibitor LY3200882 [NCIt concept]
- TGFbeta Inhibitor TU2218 [NCIt concept]

Keyword's position in hierarchy(ies) :

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