Receptor, Transforming Growth Factor-beta Type I

Preferred Label : Receptor, Transforming Growth Factor-beta Type I;

MeSH definition : A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE II TGF-BETA RECEPTORS to bind TGF-BETA and regulate a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.;

MeSH synonym : TGF-beta Type I Receptor; TGF beta Type I Receptor; TGF-beta Type I Receptors; TGF beta Type I Receptors; TbetaR-I Kinase; Kinase, TbetaR-I; TbetaR I Kinase; Type I TGF-beta Receptors; Type I TGF beta Receptors; TGF-beta RPK; Receptor, TGF-beta Type I; Activin Receptor-like Kinase 5; Activin Receptor like Kinase 5; Serine-Threonine-Protein Kinase Receptor R4; Serine Threonine Protein Kinase Receptor R4; Transforming Growth Factor beta Receptor I; Transforming Growth Factor, beta Receptor 1; TGFBR1; TGF-beta Receptor Protein Kinase; TGF beta Receptor Protein Kinase; Type I TGF-beta Receptor; Type I TGF beta Receptor;

Registry Number MeSH : EC 2.7.11.30;

UNII : EC 2.7.11.30;

Details

Origin ID

D000077293;

UMLS CUI

C0292688;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Currated CISMeF NLP mapping
- TGF-Beta Receptor Type-1 [NCIt concept]
Record concept(s)
- Receptor, Transforming Growth Factor-beta Type I [MeSH concept]
Related MeSH Supplementary Concept(s)
- TGFBR1 protein, human [MeSH Supplementary Concept]
- Tgfbr1 protein, mouse [MeSH Supplementary Concept]
- Tgfbr1 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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