Adherens Junction Assembly Pathway

Preferred Label : Adherens Junction Assembly Pathway;

NCIt related terms : Adherens junction;

Alternative definition : KEGG: Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.;

KEGG ID : hsa04520;

Details

Origin ID

C91462;

UMLS CUI

C2984274;

Automatic exact mappings (from CISMeF team)
- Adherens junction [FMA entity]
- adherens junction [GO term]
- adherens junctions [MeSH concept]
- adherens junctions [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Actin Nucleation-Promoting Factor WAS [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Actin-Binding Protein WASF2 [NCIt concept]
- Actin-Binding Protein WASF3 [NCIt concept]
- Afadin [NCIt concept]
- Alpha-Actinin-1 [NCIt concept]
- Alpha-Actinin-4 [NCIt concept]
- Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Cadherin-1 [NCIt concept]
- Casein Kinase II Subunit Alpha [NCIt concept]
- Catenin Alpha-1 [NCIt concept]
- Catenin Alpha-2 [NCIt concept]
- Catenin Alpha-3 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Nectin-1 [NCIt concept]
- Nectin-2 [NCIt concept]
- Nectin-4 [NCIt concept]
- Neural Wiskott-Aldrich Syndrome Protein [NCIt concept]
- Partitioning Defective 3 Homolog [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Beta [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Eta [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Tight Junction Protein ZO-1 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tyrosine-Protein Kinase Fer [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase Yes [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
- Vinculin [NCIt concept]
- Zinc Finger Protein SNAI2 [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- ACTN1 wt Allele [NCIt concept]
- ACTN4 wt Allele [NCIt concept]
- AFDN wt Allele [NCIt concept]
- BAIAP2 wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- CSNK2A1 wt Allele [NCIt concept]
- CTNNA1 wt Allele [NCIt concept]
- CTNNA2 wt Allele [NCIt concept]
- CTNNA3 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- FER wt Allele [NCIt concept]
- FGFR1 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- NECTIN1 wt Allele [NCIt concept]
- NECTIN2 wt Allele [NCIt concept]
- NECTIN4 wt Allele [NCIt concept]
- PARD3 wt Allele [NCIt concept]
- PTPN1 wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- PTPRB wt Allele [NCIt concept]
- PTPRJ wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SNAI2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TJP1 wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]
- WAS wt Allele [NCIt concept]
- WASF2 wt Allele [NCIt concept]
- WASF3 wt Allele [NCIt concept]
- WASL wt Allele [NCIt concept]
- YES1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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