Partitioning Defective 3 Homolog

Preferred Label : Partitioning Defective 3 Homolog;

NCIt synonyms : Atypical PKC Isotype-Specific Interacting Protein; ASIP; CTCL Tumor Antigen Se2-5; PAR3-Alpha; Par-3 Partitioning Defective 3 Homolog; Atypical PKC Isotype-Specific-Interacting Protein;

NCIt definition : Partitioning defective 3 homolog (1356 aa, 151 kDa) is encoded by the human PARD3 gene. This protein is involved in signal transduction, tight junction formation and asymmetric cell division.;

NCIt note : Partitioning defective 3 homolog complexes with either partitioning defective 6 homolog alpha or beta. This complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. (UniProt);

Details

Origin ID

C125529;

UMLS CUI

C4085255;

Automatic exact mappings (from CISMeF team)
- Agouti signaling protein [OMIM gene]
- Par3 family cell polarity regulator [OMIM gene]
- par-3 family cell polarity regulator [HGNC gene]
OMIM relation
- Par3 family cell polarity regulator [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- PARD3 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cell Junction [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- PDZ Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Division Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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