SRC wt Allele - CISMeF

Preferred Label : SRC wt Allele;

NCIt synonyms : SRC1; v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog wt Allele; ASVSRC1; ASV; c-SRC; Protooncogene SRC, Rous Sarcoma Gene; THC6;

NCIt definition : Human SRC wild-type allele is located within 20q12-q13 and is approximately 61 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase Src protein, plays a role in signal transduction pathways involved in the inhibition of endothelial cell apoptosis, regulation of the actin cytoskeleton, and the production of gonadotropins in pituitary cells. An allelic variant of the SRC gene, which produces a truncated, inactive protein, is associated with the development and metastasis of both breast and colon cancer.;

GenBank Accession Number : NM_005417;

Details

Origin ID

C51124;

UMLS CUI

C1705997;

OMIM relation
- Src protooncogene, nonreceptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 20q12-q13 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- Adherens Junction Formation Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Arf6 Signaling Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Atypical NF-kappaB Signaling Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- CXCR3-Mediated Signaling Pathway [NCIt concept]
- Calpain-1 Cell Spread Pathway [NCIt concept]
- Cell to Cell Adhesion Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- E-Cadherin Signaling Pathway in Keratinocytes [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Endothelin Pathway [NCIt concept]
- Ephrin A2 Forward Signaling Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- GABA Receptor Life Cycle Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- HBx Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- Oocyte Maturation Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- PTP4A Family Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Pelp1 Estrogen Receptor Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Regulation of Apoptosis Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
- SRC Tyrosine Kinase Activation Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 3 Signaling Pathway [NCIt concept]
- Splicing Regulation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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