Extracellular Matrix Binding Pathway

Preferred Label : Extracellular Matrix Binding Pathway;

NCIt related terms : Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia;

Alternative definition : BIOCARTA: Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ecmPathway;

Details

Origin ID

C39054;

UMLS CUI

C1517051;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Calpain-1 Catalytic Subunit [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Gelsolin [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- Paxillin [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Profilin-1 [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Rho GTPase-Activating Protein 5 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Zyxin [NCIt concept]
pathway_has_gene_element
- ARHGAP5 wt Allele [NCIt concept]
- ARHGEF1 wt Allele [NCIt concept]
- CAPN1 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GSN wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- PFN1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- ZYX wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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