Calpain-1 Catalytic Subunit

Preferred Label : Calpain-1 Catalytic Subunit;

NCIt synonyms : Micromolar-Calpain; CANP 1; EC 3.4.22.52; Cell Proliferation-Inducing Gene 30 Protein; Mu-Calpain; Calpain Mu-Type; Cell Proliferation-Inducing Protein 30; Calpain-1 Large Subunit; MuCANP; Calcium-Activated Neutral Proteinase 1; CAPN1;

NCIt definition : Calpain-1 catalytic subunit (714 aa, 82 kDa) is encoded by the human CAPN1 gene. This protein is involved in proteolysis and the regulation of signal transduction and cytoskeletal modeling.;

Details

Origin ID

C123839;

UMLS CUI

C1436406;

Automatic exact mappings (from CISMeF team)
- Calpain 1 [OMIM gene]
- calpain 1 [ORDO Gene]
- calpain complex [GO term]
- mu-calpain [MeSH concept]
- mu-calpain [MeSH Supplementary Concept]
OMIM relation
- Calpain 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CAPN1 protein, human [MeSH Supplementary Concept]
- CAPN1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CAPN1 Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Calpain [NCIt concept]
gene_product_has_structural_domain_or_motif
- EF-Hand Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway BioCarta [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Calpain-1 Cell Spread Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Extracellular Matrix Degradation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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