Calpain-1 Cell Spread Pathway

Preferred Label : Calpain-1 Cell Spread Pathway;

NCIt synonyms : mu-Calpain Cell Spread Pathway; uCalpain Cell Spread Pathway;

NCIt related terms : uCalpain and friends in Cell spread;

Alternative definition : BIOCARTA: The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. Spreading cells display newly transiently formed integrin adhesion clusters containing Calpain1 (mu-Calpain), cleaved Talin, B3-Integrin, and SPTAN1 (Spectrin). Recruitment of Rac to these clusters leads to the activation of Rac and the formation of Rac-induced focal clusters. The Calpain1 in the integrin clusters initially inactivates RhoA allowing for the formation of lamellipodia. The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers. These mature adhesions do not contain calpain. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ucalpainPathway;

Details

Origin ID

C39262;

UMLS CUI

C1515818;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- Calpain-1 Catalytic Subunit [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Paxillin [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- CAPN1 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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