Extracellular Matrix Degradation

Preferred Label : Extracellular Matrix Degradation;

NCIt definition : Extracellular Matrix Degradation consists of conjugation, transport, oxidation, and/or proteolysis of the supporting meshwork-like network of fibers and substances in the extracellular space or basement membrane to which cells adhere and that promotes cell proliferation. Extracellular Matrix is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.;

Details

Origin ID

C41580;

UMLS CUI

C1517052;

Semantic type(s)
- Cell Function [UMLS semantic type]
biological_process_involves_gene_product
- C-Type Mannose Receptor 2 [NCIt concept]
- Calpain-1 Catalytic Subunit [NCIt concept]
- Chymase [NCIt concept]
- Collagenase 3 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 15 [NCIt concept]
- Heparanase-2 [NCIt concept]
- Matrilysin [NCIt concept]
- SH3 and PX Domain-Containing Protein 2A [NCIt concept]
- SH3 and PX Domain-Containing Protein 2B [NCIt concept]
- Stromelysin-2 [NCIt concept]
- Transmembrane Protease Serine 6 [NCIt concept]
- Versican Core Protein [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Incyclinide [NCIt concept]
- Rebimastat [NCIt concept]
process_involves_gene
- CAPN1 Gene [NCIt concept]
- CAPN1 wt Allele [NCIt concept]
- CMA1 Gene [NCIt concept]
- CMA1 wt Allele [NCIt concept]
- HPSE2 Gene [NCIt concept]
- HPSE2 wt Allele [NCIt concept]
- MMP10 Gene [NCIt concept]
- MMP10 wt Allele [NCIt concept]
- MMP13 Gene [NCIt concept]
- MMP13 wt Allele [NCIt concept]
- MMP7 Gene [NCIt concept]
- MMP7 wt Allele [NCIt concept]
- MRC2 Gene [NCIt concept]
- MRC2 wt Allele [NCIt concept]
- SH3PXD2A Gene [NCIt concept]
- SH3PXD2A wt Allele [NCIt concept]
- SH3PXD2B Gene [NCIt concept]
- SH3PXD2B wt Allele [NCIt concept]
- TMPRSS6 Gene [NCIt concept]
- TMPRSS6 wt Allele [NCIt concept]
- VCAN Gene [NCIt concept]
- VCAN wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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