Rebimastat - CISMeF

Preferred Label : Rebimastat;

NCIt synonyms : N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide;

NCIt related terms : BMS-275291;

NCIt definition : A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called matrix metalloproteinase inhibitors (MMPIs).;

UNII : 1B47R6ZX4K;

InChIKey : GTXSRFUZSLTDFX-HRCADAONSA-N;

CAS number : 259188-38-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 259188-38-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BMS-275291; D2163;

Chemical formula : C23H41N5O5S;

NSC code : 713763;

Codes from synonyms : 50521; CDR0000044972; 110498;

Details

Origin ID

C1875;

UMLS CUI

C1688557;

Automatic exact mappings (from CISMeF team)
- N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide [MeSH concept]
- N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide [MeSH Supplementary Concept]
- N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3- dimethyl-L-Valinamide [MeSH concept]
chemical_or_drug_affects_gene_product
- 72 kDa Type IV Collagenase [NCIt concept]
- Interstitial Collagenase [NCIt concept]
- Matrix Metalloproteinase-14 [NCIt concept]
- Matrix Metalloproteinase-9 [NCIt concept]
- Neutrophil Collagenase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Extracellular Matrix Degradation [NCIt concept]
- Metastasis Suppression [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- 72 kDa Type IV Collagenase [NCIt concept]
- Interstitial Collagenase [NCIt concept]
- Matrix Metalloproteinase-14 [NCIt concept]
- Matrix Metalloproteinase-9 [NCIt concept]
- Neutrophil Collagenase [NCIt concept]
is_component_of_chemotherapy_regimen
- BMS-275291/Carboplatin/Paclitaxel [NCIt concept]
- BMS-275291/Zoledronate [NCIt concept]

Keyword's position in hierarchy(ies) :

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