Preferred Label : Rebimastat;
NCIt synonyms : N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide;
NCIt related terms : BMS-275291;
NCIt definition : A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with
potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP
1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting
angiogenesis, tumor growth and invasion, and metastasis.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called matrix metalloproteinase inhibitors (MMPIs).;
UNII : 1B47R6ZX4K;
InChIKey : GTXSRFUZSLTDFX-HRCADAONSA-N;
CAS number : 259188-38-0;
Molecule name : BMS-275291; D2163;
Chemical formula : C23H41N5O5S;
NSC code : 713763;
Codes from synonyms : 50521; CDR0000044972; 120714;
Origin ID : C1875;
UMLS CUI : C1688557;
Automatic exact mappings (from CISMeF team)
Semantic type(s)
UMLS correspondences (same concept)
chemical_or_drug_affects_gene_product
chemical_or_drug_has_mechanism_of_action
chemical_or_drug_has_physiologic_effect
concept_is_in_subset
has_target
is_component_of_chemotherapy_regimen