Disintegrin and Metalloproteinase Domain-Containing Protein 15

Preferred Label : Disintegrin and Metalloproteinase Domain-Containing Protein 15;

NCIt synonyms : MDC15; A Disintegrin and Metalloproteinase Domain 15; ADAM15; Metalloproteinase-Like Disintegrin-Like and Cysteine-Rich Protein 15; Metargidin; EC 3.4.24.-; Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 15; ADAM 15; MDC-15; Metalloprotease RGD Disintegrin Protein; Metalloprotease-RGD-Disintegrin Protein;

NCIt definition : Disintegrin and metalloproteinase domain-containing protein 15 (863 aa, 93 kDa) is encoded by the human ADAM15 gene. This protein is involved in cell-cell interactions, extracellular matrix protein metabolism and cell adhesion.;

NCIt note : The RGD domain of ADAM15 appears to interact with integrin alpha5/beta3 or integrin alpha5/beta1, but not with other integrins.;

Details

Origin ID

C17986;

UMLS CUI

C1313290;

False automatic mappings
- atroxase [MeSH Supplementary Concept]
- jararafibrase I [MeSH Supplementary Concept]
- jararafibrase IV [MeSH Supplementary Concept]
OMIM relation
- A disintegrin and metalloproteinase domain 15 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ADAM15 protein, human [MeSH concept]
- ADAM15 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- ADAM15 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- ADAM Family Protein [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ADAM Type Metalloprotease Domain [NCIt concept]
- Disintegrin Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Extracellular Matrix Degradation [NCIt concept]
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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