ADAM Family Protein

Preferred Label : ADAM Family Protein;

NCIt definition : The ADAM family consists of transmembrane proteins that contain a disintegrin and metalloprotease domain. By virtue of these domains they have the potent for both cell adhesion and protease activities. Currently, the ADAM family has 29 membranes, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response.;

Details

Origin ID

C21145;

UMLS CUI

C1332023;

Automatic exact mappings (from CISMeF team)
- adam proteins [MeSH Descriptor]
Biochemical function of gene products
- Disintegrin and Metalloproteinase Domain-Containing Protein 10 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 11 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 12 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 15 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 17 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 19 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 33 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 8 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 9 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Metallopeptidase [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- ADAM Type Metalloprotease Domain [NCIt concept]
- Disintegrin Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Integrin Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients