Disintegrin and Metalloproteinase Domain-Containing Protein 12

Preferred Label : Disintegrin and Metalloproteinase Domain-Containing Protein 12;

NCIt synonyms : ADAM 12; Meltrin-Alpha; EC 3.4.24.-; ADAM12;

NCIt definition : Disintegrin and metalloproteinase domain-containing protein 12 (909 aa, 100 kDa) is encoded by the human ADAM12 gene. This protein plays a role in proteolysis, signaling and cell adhesion.;

NCIt note : Four isoforms of disintegrin and metalloproteinase domain-containing protein 12 are produced by alternate splicing. Isoform 1 is a type I transmembrane protein and isoforms 2, 3 and 4 are secreted.;

Details

Origin ID

C96039;

UMLS CUI

C3272510;

OMIM relation
- A disintegrin and metalloproteinase domain 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ADAM12 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ADAM12 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_biochemical_function
- ADAM Family Protein [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- ADAM Type Metalloprotease Domain [NCIt concept]
- Disintegrin Domain [NCIt concept]
- EGF-Like Domain [NCIt concept]
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Cardiac Hypertrophy Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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