ADAM Type Metalloprotease Domain

Preferred Label : ADAM Type Metalloprotease Domain;

NCIt definition : ADAMs are transmembrane proteins containing both a disintegrin and a metalloprotease domain. Two thirds of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern which locates the active site of these proteases. As they contain an adhesion domain and a protease domain, ADAM proteins potentially have both cell adhesion and protease activities. They play a role in various biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and inflammatory response. In ADAMTS proteins, a closely related family of proteases, the metalloprotease and disintegrin domains are flanked by thrombospondin type I (TSP1) repeat. ADAMTS proteins are soluble, extracellular matrix proteases. (From InterPro IPR001590);

Details

Origin ID

C25863;

UMLS CUI

C1510683;

Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- ADAM Family Protein [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 10 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 11 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 12 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 15 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 17 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 19 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 33 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 8 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 9 [NCIt concept]

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