Heparanase-2 - CISMeF

Preferred Label : Heparanase-2;

NCIt synonyms : Hpa2; HPSE2;

NCIt definition : Heparanase-2 (592 aa, 67 kDa) is encoded by the human HPSE2 gene. This protein is involved in the proteolysis of heparan sulfate proteoglycans.;

NCIt note : The enzymatic activity of heparanase-2 may play a role in metastasis and angiogenesis; making it a potential target for anti-cancer therapy.;

Details

Origin ID

C91278;

UMLS CUI

C1433151;

Automatic exact mappings (from CISMeF team)
- HPA-2 [LOINC component]
- Heparanase 2 [OMIM gene]
- Platelet groups--ko system [OMIM Phenotype]
- heparanase 2 (inactive) [ORDO Gene]
OMIM relation
- Heparanase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HPSE2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HPSE2 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Extracellular Matrix Degradation [NCIt concept]
- Hydrolysis [NCIt concept]
- Metastasis [NCIt concept]
- Neovascularization [NCIt concept]

Keyword's position in hierarchy(ies) :

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