" /> Incyclinide - CISMeF





Preferred Label : Incyclinide;

NCIt synonyms : 4-Dimethlyamino Sancycline; Tetracycline CMT-3; 4-Dimethlyaminosancycline; 6-deoxy-6-demethyl-4-dedimethylaminotetracycline; 4-dedimethylamino sancycline; 6-deoxy, 6-demethyl, 4-de-dimethylamino tetracycline;

NCIt related terms : Metastat; COL-3;

NCIt definition : A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. COL-3 may block the growth of new blood vessels that tumors need to grow. It is a type of matrix metalloproteinase inhibitor and a type of antiangiogenesis agent.;

UNII : 21G64WZQ4I;

InChIKey : ZXFCRFYULUUSDW-OWXODZSWSA-N;

CAS number : 15866-90-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 15866-90-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Metastat;

Molecule name : COL 3; COL-3; CMT-3;

Chemical formula : C19H17NO7;

NSC code : 683551;

Codes from synonyms : 31767; CDR0000045574;

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15/05/2024


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