Matrix Metalloproteinase

Preferred Label : Matrix Metalloproteinase;

NCIt synonyms : MMP; Matrix Metalloprotease;

NCIt definition : Matrix metalloproteinases are Zn(2 )-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. Matrix metalloproteinases have been associated with the development of advanced-stage cancer via their role in tumor progression, invasion, and metastasis.;

Codes from synonyms : CDR0000044211;

Details

Origin ID

C18164;

UMLS CUI

C0623362;

Automatic exact mappings (from CISMeF team)
- matrix metalloproteinases [medical devices type]
- obsolete matrilysin activity [GO term]
Currated CISMeF NLP mapping
- matrix metalloproteinases [MeSH Descriptor]
- matrix metalloproteinases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- matrix metalloproteinases [MeSH concept]
- matrix metalloproteinases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Incyclinide [NCIt concept]
- Shark Cartilage [NCIt concept]
- Shark Cartilage Extract AE-941 [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
is_target
- Incyclinide [NCIt concept]
- Shark Cartilage Extract AE-941 [NCIt concept]

Keyword's position in hierarchy(ies) :

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