Shark Cartilage Extract AE-941

Preferred Label : Shark Cartilage Extract AE-941;

NCIt related terms : Neovastat; AE-941;

NCIt definition : A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.;

Alternative definition : NCI-GLOSS: A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.;

CAS number : 305838-77-1;

Drug name : Neovastat;

Molecule name : AE-941; [AElig]-941;

NSC code : 706456;

Codes from synonyms : CDR0000045103; 31675;

Details

Origin ID

C1798;

UMLS CUI

C1963096;

Currated CISMeF NLP mapping
- AE-941 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AE-941 [MeSH concept]
Validated automatic mappings to NTBT
- shark cartilage extract [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Vascular Endothelium [NCIt concept]
chemical_or_drug_affects_gene_product
- Matrix Metalloproteinase [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
- Negative Regulation of Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Growth Factor Inhibition [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Matrix Metalloproteinase [NCIt concept]
- Tissue-Type Plasminogen Activator [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Neovastat/Paclitaxel [NCIt concept]
- Cisplatin/Neovastat/Vinorelbine [NCIt concept]

Keyword's position in hierarchy(ies) :

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