NCIt definition : A multifunctional antiangiogenic agent derived from shark cartilage with potential
antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the
binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular
receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits
matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and
activates caspase-mediated apoptotic pathways in endothelial cells.;
Alternative definition : NCI-GLOSS: A substance made from shark cartilage that is being studied for its ability
to prevent the growth of new blood vessels that tumors need to grow. It is a type
of antiangiogenesis agent.;
CAS number : 305838-77-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 305838-77-1
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