Tissue-Type Plasminogen Activator

Preferred Label : Tissue-Type Plasminogen Activator;

NCIt synonyms : TPA; T-Plasminogen Activator; t-PA; PLAT; EC 3.4.21.68;

NCIt related terms : tissue plasminogen activator;

NCIt definition : Tissue-type plasminogen activator (562 aa, 63 kDa) is encoded by the human PLAT gene. This protein plays a role in the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.;

Alternative definition : NCI-GLOSS: An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator is a type of systemic thrombolytic agent.;

NCIt note : Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin, tissue kallikrein or factor Xa to a two chain disulfide linked protein. The two chain form demonstrates increased levels of plasminogen-plasmin converting activity when compared to the single chain form.;

NCI Metathesaurus CUI : CL507763;

Codes from synonyms : CDR0000377721; CDR0000377718;

Details

Origin ID

C16995;

UMLS CUI

C0084796;

Automatic exact mappings (from CISMeF team)
- Alteplase [ICHI extension code]
- Plasminogen activator (tissue) [ICHI extension code]
- Plasminogen activator, tissue [OMIM gene]
- obsolete plasminogen activator activity [GO term]
- plasminogen activator, tissue type [ORDO Gene]
- tPA stop [MeSH concept]
- tPA stop [MeSH Supplementary Concept]
- taurine-pyruvate aminotransferase activity [GO term]
- thyroid hyalinizing trabecular adenoma [DO Concept]
OMIM relation
- Plasminogen activator, tissue [OMIM gene]
See also inter- (CISMeF)
- Product containing alteplase (medicinal product) [SNOMED CT concept]
- Product containing tissue plasminogen activator (medicinal product) [SNOMED CT concept]
- Reteplase (substance) [SNOMED CT concept]
- reteplase [ATC Code]
- reteplase [MeSH concept]
- reteplase [MeSH Supplementary Concept]
- reteplase [International Nonproprietary Name]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- PLAT protein, human [MeSH concept]
- PLAT protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- activase [MeSH concept]
- alteplase [ATC Code]
- alteplase [ATC Code]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Alteplase [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PLAT Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelial Cell [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Kringle Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myocardial Infarction Pathway [NCIt concept]
- Fibrinolysis Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Migration Process [NCIt concept]
- Coagulation Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Shark Cartilage Extract AE-941 [NCIt concept]

Keyword's position in hierarchy(ies) :

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