tissue plasminogen activator

Preferred Label : tissue plasminogen activator;

MeSH definition : A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.;

MeSH synonym : alteplase; plasminogen activator, tissue type; tissue-type plasminogen activator; t plasminogen activator; tissue activator d 44; plasminogen activator, tissue; tissue activator d-44; Tisokinase; tissue type plasminogen activator; ttpa; t-plasminogen activator; plasminogen activator, tissue-type;

CISMeF synonym : activator, t-plasminogen; activator, tissue plasminogen; activator, tissue-type plasminogen; Hoffmann-La roche brand of alteplase; alteplase genentech brand; alteplase promeco brand; boehringer ingelheim brand of alteplase; genentech brand of alteplase; hoffmann la roche brand of alteplase; promeco brand of alteplase;

MeSH hyponym : actilyse; activase; Lysatec rt-PA; Lysatec rt PA; Lysatec rtPA;

MeSH Related Number : 105857-23-6 (Alteplase);

Registry Number MeSH : EC 3.4.21.68;

Wikipedia link : https://en.wikipedia.org/wiki/Tissue plasminogen activator;

Is substance : O;

UNII : EC 3.4.21.68;

Details

Origin ID

D010959;

UMLS CUI

C0032143;

ATC code(s)
- alteplase [ATC Code]
ATC code(s)
- alteplase [ATC Code]
- alteplase [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Active Ingredient [NCIt concept]
- Alkaline phosphatase [BNCI exam]
- Alteplase [ICHI extension code]
- Pascal (qualifier value) [SNOMED CT concept]
- Plasminogen Activator [NCIt concept]
- Plasminogen activator (tissue) [ICHI extension code]
- Plasminogen activator, tissue [OMIM gene]
- Tocopherol transfer protein, alpha [OMIM gene]
- activator tissue plasminogen [medical devices type]
- alpha tocopherol transfer protein [ORDO Gene]
- plasminogen activation [GO term]
- plasminogen activator, tissue type [ORDO Gene]
- plasminogen activator, tissue type [HGNC gene]
- tissue plasminogen activator [EMDN type]
Currated CISMeF NLP mapping
- Alteplase [ICD-11 Extension code]
- Alteplase [NCIt concept]
- Alteplase (substance) [SNOMED CT concept]
- Plasminogen activator tissue type [LOINC component]
- Tissue plasminogen activator [ICD-11 Extension code]
- Tissue plasminogen activator (substance) [SNOMED CT concept]
- Tissue-Type Plasminogen Activator [NCIt concept]
- alteplase [SNOMED Notion]
- alteplase [International Nonproprietary Name]
- tissue plasminogen activator [SNOMED Notion]
Exact mapping(s) to DCI
- alteplase [International Nonproprietary Name]
Indexing information
- E 6010 [MeSH Supplementary Concept]
- N-stearoyl-seryl-proline ethyl ester [MeSH Supplementary Concept]
- tPA stop [MeSH Supplementary Concept]
Pharmacological action(s)
- fibrinolytic agents [MeSH Descriptor]
Record concept(s)
- actilyse [MeSH concept]
- activase [MeSH concept]
- tissue plasminogen activator [MeSH concept]
Related MeSH Supplementary Concept(s)
- D-K2P [MeSH Supplementary Concept]
- FK2P tissue plasminogen activator [MeSH Supplementary Concept]
- LY 210825 [MeSH Supplementary Concept]
- PLAT protein, human [MeSH Supplementary Concept]
- T103N [MeSH Supplementary Concept]
- T103N, KHRR 296-299 AAAA [MeSH Supplementary Concept]
- TNK-tissue plasminogen activator [MeSH Supplementary Concept]
- amediplase [MeSH Supplementary Concept]
- arginyl-asparagyl-prolyl-aspartyl-glycyl-aspartyl-alanyl-lysyl-prolyl-tryptophan [MeSH Supplementary Concept]
- delta(2-89)-tissue plasminogen activator [MeSH Supplementary Concept]
- duteplase [MeSH Supplementary Concept]
- lanoteplase [MeSH Supplementary Concept]
- lekteplase [MeSH Supplementary Concept]
- pamiteplase [MeSH Supplementary Concept]
- reteplase [MeSH Supplementary Concept]
- technetium tc 99m-tissue-type plasminogen activator [MeSH Supplementary Concept]
- thrombophilia, familial, due to decreased release of tissue plasminogen activator [MeSH Supplementary Concept]
- tissue plasminogen activator-(staphylococcal A, B fragment) dimer [MeSH Supplementary Concept]
- unglycosylated rt-PA [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- plasminogen [MeSH Descriptor]
See also inter- (CISMeF)
- Product containing alteplase (medicinal product) [SNOMED CT concept]
- Product containing tissue plasminogen activator (medicinal product) [SNOMED CT concept]
- Substance with plasminogen activator mechanism of action (substance) [SNOMED CT concept]
- obsolete plasminogen activator activity [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alteplase [NCIt concept]
- Alteplase (substance) [SNOMED CT concept]
- Plasminogen activator tissue type [LOINC component]
- Product containing alteplase (medicinal product) [SNOMED CT concept]
- Product containing tissue plasminogen activator (medicinal product) [SNOMED CT concept]
- Tissue plasminogen activator (substance) [SNOMED CT concept]
- alteplase [ATC Code]
- alteplase [ATC Code]
- alteplase [International Nonproprietary Name]
- alteplase [SNOMED Notion]
- tissue plasminogen activator [SNOMED Notion]
Validated automatic mappings to BTNT
- alteplase [ATC Code]
- alteplase [ATC Code]
Validated automatic mappings to NTBT
- plasminogen activator, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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