Alteplase - CISMeF

Preferred Label : Alteplase;

NCIt synonyms : Plasminogen Activator (Human Tissue-Type Protein Moiety); rt-PA; Recombinant Tissue Plasminogen Activator;

NCIt related terms : r-tPA; Activase;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.;

Alternative definition : NCI-GLOSS: A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.;

UNII : 1RXS4UE564;

CAS number : 105857-23-6;

Drug name : Activase;

Codes from synonyms : CDR0000377722; CDR0000377725; CDR0000377724; CDR0000373954;

Details

Origin ID

C39607;

UMLS CUI

C0032143;

Automatic exact mappings (from CISMeF team)
- Rt-PA [ICHI extension code]
See also inter- (CISMeF)
- Product containing alteplase (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alteplase (substance) [SNOMED CT concept]
- Plasminogen activator tissue type [LOINC component]
- Product containing alteplase (medicinal product) [SNOMED CT concept]
- Product containing tissue plasminogen activator (medicinal product) [SNOMED CT concept]
- Tissue plasminogen activator (substance) [SNOMED CT concept]
- alteplase [ATC Code]
- alteplase [ATC Code]
- alteplase [International Nonproprietary Name]
- alteplase [SNOMED Notion]
- tissue plasminogen activator [MeSH concept]
- tissue plasminogen activator [SNOMED Notion]
- tissue plasminogen activator [MeSH Descriptor]
Validated automatic mappings to BTNT
- alteplase [ATC Code]
- alteplase [ATC Code]
Validated automatic mappings to NTBT
- TISSUE PLASMINOGEN ACTIVATOR [SMS substance]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Captopril/Tissue Plasminogen Activator [NCIt concept]
is_related_to_endogenous_product
- Tissue-Type Plasminogen Activator [NCIt concept]

Keyword's position in hierarchy(ies) :

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