Preferred Label : Platelet Amyloid Precursor Protein Pathway;
Alternative definition : BIOCARTA: The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor
protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's
disease. Platelets contain both APP and Ab and probably contribute greater than 90%
of circulating APP. The soluble APP is the major inhibitor of coagulation factors
IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine
and collagen activate the release of APP and plasminogen activator inhibitor I (an
important regulator of coagulation) from platelet storage granules. These important
molecules released from platelets are key regulators of hemostasis, the physiologic
arrest of hemorrhage at site of vascular leakage. (This definition may be outdated
- see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_plateletAppPathway;
Origin ID : C39191;
UMLS CUI : C1514160;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
