PLAU wt Allele

Preferred Label : PLAU wt Allele;

NCIt synonyms : UPA; Plasminogen Activator, Urokinase wt Allele; URK; u-PA; RP11-417O11.1; BDPLT5; QPD;

NCIt definition : Human PLAU wild-type allele is located within 10q24 and is approximately 6 kb in length. This allele, which encodes urokinase-type plasminogen activator protein, plays a role in the degradation of the extracellular matrix via activation of plasminogen. Overexpression of the PLAU gene is associated with cancer progression.;

GenBank Accession Number : NM_002658;

Details

Origin ID

C50373;

UMLS CUI

C1706177;

Automatic exact mappings (from CISMeF team)
- Plasminogen activator, urinary [OMIM gene]
- Quebec platelet disorder [OMIM Phenotype]
- Quebec platelet disorder [DO Concept]
- Urokinase-Type plasminogen activator [MeSH Descriptor]
- obsolete plasminogen activator activity [GO term]
- plasminogen activator, urokinase [ORDO Gene]
- uridylyl-(3'-5')-adenosine [MeSH Supplementary Concept]
- uridylyl-(3'-5')-adenosine [Substance BNPC]
OMIM relation
- Plasminogen activator, urinary [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Alzheimer's Disease [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 10q24 [NCIt concept]
gene_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Fibrinolysis Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
gene_plays_role_in_process
- Hydrolysis [NCIt concept]
- Negative Regulation of Coagulation [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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