Urokinase-Type plasminogen activator

Preferred Label : Urokinase-Type plasminogen activator;

MeSH definition : A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.;

MeSH synonym : plasminogen activator, urokinase-type; u-plasminogen activator; u plasminogen activator; u-pa; urinary plasminogen activator; urokinase; urokinase type plasminogen activator;

CISMeF synonym : UPA; activator, urinary plasminogen; activator, u-plasminogen; plasminogen activator, urinary;

MeSH hyponym : Single-Chain Urokinase-Type plasminogen activator; kidney plasminogen activator; abbokinase; renokinase; Single Chain Urokinase Type Plasminogen Activator;

MeSH Related Number : 9039-53-6 (CAS RN);

Registry Number MeSH : EC 3.4.21.73;

Is substance : O;

UNII : EC 3.4.21.73;

Details

Origin ID

D014568;

UMLS CUI

C0042071;

ATC code(s)
- urokinase [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid [MeSH Supplementary Concept]
- 2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine [MeSH Supplementary Concept]
- 2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine [MeSH Supplementary Concept]
- 3,4-dihydro-3,4-dibromo-6-bromomethylcoumarin [MeSH Supplementary Concept]
- 4-iodine-benzo(b)thiophene-2-carboxamidine [MeSH Supplementary Concept]
- 5,14-dioxo-12-(2-phenylalanine-N-ylethyl-1-yl)-1,2,3,5,5a,6,11,12,14,14a-decahydro-5H,14H-pyrolo(1,2-4,5)pyrazino(1,2-1,6)pyrido(3,4-b)indole [MeSH Supplementary Concept]
- B 623 [MeSH Supplementary Concept]
- N(alpha)-benzoylarginineamide [MeSH Supplementary Concept]
- epigallocatechin gallate [MeSH Supplementary Concept]
- glutamyl-glycyl-arginine chloromethyl ketone [MeSH Supplementary Concept]
- methyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-guanidinophenyl)ethylcarbamate [MeSH Supplementary Concept]
- methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate [MeSH Supplementary Concept]
- mupain-1 [MeSH Supplementary Concept]
- upain-1 peptide [MeSH Supplementary Concept]
- upamostat [MeSH Supplementary Concept]
- urokinase inhibitor [MeSH Supplementary Concept]
Record concept(s)
- Single-Chain Urokinase-Type plasminogen activator [MeSH concept]
- Urokinase-Type plasminogen activator [MeSH concept]
- abbokinase [MeSH concept]
- kidney plasminogen activator [MeSH concept]
- renokinase [MeSH concept]
Related MeSH Supplementary Concept(s)
- M23 urokinase [MeSH Supplementary Concept]
- PAItrap peptide [MeSH Supplementary Concept]
- SLURP-1 protein, mouse [MeSH Supplementary Concept]
- SLURP-1 protein, rat [MeSH Supplementary Concept]
- SLURP1 protein, human [MeSH Supplementary Concept]
- acetyl-lysyl-prolyl-seryl-seryl-prolyl-prolyl-glutamyl-glutamic acid amide [MeSH Supplementary Concept]
- amediplase [MeSH Supplementary Concept]
- antagosan [MeSH Supplementary Concept]
- cyclo(19,31)-urokinase-type plasminogen activator (19-31) [MeSH Supplementary Concept]
- fibrinolytic agent LTI-01 [MeSH Supplementary Concept]
- nasaruplase [MeSH Supplementary Concept]
- plasmin heavy chain-urokinase conjugate [MeSH Supplementary Concept]
- preprourokinase [MeSH Supplementary Concept]
- saruplase [MeSH Supplementary Concept]
- urokinase A chain 149-157 [MeSH Supplementary Concept]
- urokinase-ATF-SAP-3, recombinant [MeSH Supplementary Concept]
- urokinase-fibrinogen conjugate [MeSH Supplementary Concept]
- urokinase-type plasminogen activator (17-34) [MeSH Supplementary Concept]
- urokinase-type plasminogen activator (6-135) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Plasminogen activator urokinase type [LOINC component]
- Product containing urokinase (medicinal product) [SNOMED CT concept]
- Urokinase (substance) [SNOMED CT concept]
- Urokinase-Type Plasminogen Activator [NCIt concept]
- urokinase [ATC Code]
- urokinase preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- Recombinant Urokinase [NCIt concept]
- urokinase [ATC Code]
Validated automatic mappings to NTBT
- Plasminogen Activator [NCIt concept]
- Substance with plasminogen activator mechanism of action (substance) [SNOMED CT concept]
- plasminogen activator, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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