Urokinase-Type Plasminogen Activator

Preferred Label : Urokinase-Type Plasminogen Activator;

NCIt synonyms : Plasminogen Activator, Urokinase; Plasminogen Activator, Urinary; U-Plasminogen Activator; Urinary Plasminogen Activator; Urokinase Plasminogen Activator; PLAU; u-PA; Urokinase; EC 3.4.21.73;

NCIt related terms : urokinase-plasminogen activator; uPA;

NCIt definition : Urokinase-type plasminogen activator (431 aa, 49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.;

Alternative definition : NCI-GLOSS: An enzyme that is made in the kidney and found in the urine. A form of this enzyme is made in the laboratory and used to dissolve blood clots or to prevent them from forming.;

NCIt note : Urokinase-type plasminogen activator is found in high and low molecular mass forms. Each form is comprised of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. (UniProt);

NCI Metathesaurus CUI : CL790344;

Codes from synonyms : CDR0000045245; CDR0000658871; CDR0000658872; CDR0000658873;

Details

Origin ID

C17242;

UMLS CUI

C4548357;

Automatic exact mappings (from CISMeF team)
- Plasminogen activator, urinary [OMIM gene]
- obsolete plasminogen activator activity [GO term]
- plasminogen activator, urokinase [HGNC gene]
- plasminogen activator, urokinase [ORDO Gene]
- uridylyl-(3'-5')-adenosine [MeSH Supplementary Concept]
- uridylyl-(3'-5')-adenosine [Substance BNPC]
- urokinase plasminogen activator [EMDN type]
- urokinase plasminogen activator [medical devices type]
OMIM relation
- Plasminogen activator, urinary [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- PLAU protein, human [MeSH Supplementary Concept]
- Plasminogen activator urokinase type [LOINC component]
- Product containing urokinase (medicinal product) [SNOMED CT concept]
- Urokinase (substance) [SNOMED CT concept]
- Urokinase-Type plasminogen activator [MeSH concept]
- Urokinase-Type plasminogen activator [MeSH Descriptor]
- urokinase [ATC Code]
- urokinase preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- urokinase [ATC Code]
Validated automatic mappings to NTBT
- plasminogen activator, nos [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Recombinant Urokinase [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PLAU Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelial Cell [NCIt concept]
gene_product_has_associated_anatomy
- Blood [NCIt concept]
- Urine [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Kringle Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Fibrinolysis Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Negative Regulation of Coagulation [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Upamostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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