Preferred Label : Upamostat;
NCIt synonyms : Serine Protease Inhibitor WX-671; 1-Piperazinecarboxylic Acid, 4-((2S)-3-(3-((E)-Amino(hydroxyimino)methyl)phenyl)-1-oxo-2-(((2,4,6-tris(1-methylethyl)phenyl)sulfonyl)amino)propyl)-,
Ethyl Ester;
NCIt related terms : WX-671;
NCIt definition : An orally bioavailable, 3-amidinophenylalanine-derived, second generation serine protease
inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system
with potential antineoplastic and antimetastatic activities. After oral administration,
upamostat is converted to the active N alpha-(2,4,6-triisopropylphenylsulfonyl)-3-amidino-(L)-phenylalanine-4-ethoxycarbonylpiperazide
(WX-UK1), which inhibits several serine proteases, particularly uPA; inhibition of
uPA may result in the inhibition of tumor growth and metastasis. uPA is a serine protease
involved in degradation of the extracellular matrix and tumor cell migration and proliferation.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It blocks the action of certain enzymes, and it may help keep cancer cells from growing
and spreading. It is a type of serine protease inhibitor.;
UNII : S5M7KW6U17;
InChIKey : HUASEDVYRABWCV-NDEPHWFRSA-N;
CAS number : 1191101-18-4;
Molecule name : WX-671;
Codes from synonyms : CDR0000561417;
Origin ID : C73985;
UMLS CUI : C3659713;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
