Amyloid-Beta Precursor Protein

Preferred Label : Amyloid-Beta Precursor Protein;

NCIt synonyms : PN II; Cerebralvascular Amyloid Peptide; Protease Nexin II; Amyloid Beta (A4) Precursor Protein; ABPP; AAA; PreA4; PN2; Protease Nexin-II, Alzheimer Disease; PN-II; Alzheimer Disease 1 Protein; Amyloid Beta-Peptide; Amyloid of Aging and Alzheimer Disease Protein; CVAP; Amyloid; APPI; Alzheimer's Disease Amyloid Protein; APP; Protease Nexin-II; Cerebral Vascular Amyloid Peptide; Amyloid Beta A4 Protein Precursor; Alzheimer Disease Amyloid Protein; Amyloid Beta-A4 Protein Precursor; Alzheimer Disease Amyloid A4 Protein Homolog; Amyloid Precursor Protein; Amyloid-Beta (A4) Precursor Protein; Amyloid-Beta A4 Protein; Amyloid Beta A4 Protein;

NCIt definition : Amyloid-beta precursor protein (770 aa, 87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, transcriptional regulatory molecules and neurotoxic fragments.;

NCIt note : Amyloid Beta A4 Protein is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor for cell mobility, adhesion, and axonogenesis/synaptogenesis, APP variants inhibit Notch signaling, regulate copper homeostasis, bind lipoproteins, activate transcription, and enhance apoptosis via G(O) and JIP pathways. NPXY is required for binding protein PID domains, endocytosis, and BaSS sorting. APP defects cause Alzheimer's disease and cerebroarterial amyloidosis.;

Details

Origin ID

C16285;

UMLS CUI

C0611285;

Currated CISMeF NLP mapping
- amyloid [MeSH Descriptor]
- amyloid [MeSH concept]
- amyloid beta-Peptides [MeSH Descriptor]
- amyloid beta-Peptides [MeSH concept]
False automatic mappings
- amyloid beta-peptide (5-40) [MeSH concept]
- amyloid beta-peptide (5-40) [MeSH Supplementary Concept]
- amyloid beta-peptide (5-42) [MeSH concept]
- amyloid beta-peptide (5-42) [MeSH Supplementary Concept]
- amyloid beta-peptide (8-14) [MeSH concept]
- amyloid beta-peptide (8-14) [MeSH Supplementary Concept]
- amyloid beta-peptide (9-42) [MeSH concept]
- amyloid beta-peptide (9-42) [MeSH Supplementary Concept]
- beta-amyloid peptide (29-42) [MeSH concept]
- beta-amyloid peptide (29-42) [MeSH Supplementary Concept]
- mobile applications [EFMI term]
OMIM relation
- Amyloid beta a4 precursor protein [OMIM gene]
See also inter- (CISMeF)
- Amyloidosis [ICD-11 Category]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- APP protein, human [MeSH Supplementary Concept]
- APP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- APP Gene [NCIt concept]
- Enzyme Inhibitor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Nucleus [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway BioCarta [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Amyloid Beta-Peptide Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alzheimer's Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Motility [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Ligand Binding [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Oxidative Stress [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Fluorine F 18 RD2 [NCIt concept]
- Fluorine F 18 W372 [NCIt concept]
- Flutemetamol F 18 [NCIt concept]

Keyword's position in hierarchy(ies) :

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