Flutemetamol F 18

Preferred Label : Flutemetamol F 18;

NCIt synonyms : 2-[3-(18F)Fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol; Flutemetamol F-18; [18F]Flutemetamol; Fluorine F 18 Flutemetamol; [18F]FPIB; [18F]GE-067;

NCIt definition : A radiopharmaceutical containing flutemetamol, a thioflavin derivative of Pittsburgh compound B (PiB) labeled with the radioisotope fluorine F18 that can be used to detect beta-amyloid deposition upon positron emission tomography (PET). After intravenous administration of flutemetamol F 18, the flutemetamol moiety selectively accumulates in and binds to cerebral fibrillar amyloid-beta in the brain. The fluorine F18 radioisotope moiety is detected using PET, which allows imaging and quantification of amyloid-beta density. Amyloid plaque deposition is linked to cognitive decline, including Alzheimer's disease, and may be linked to chemotherapy-induced cognitive impairment (CICI).;

UNII : L49M066S0O;

InChIKey : VVECGOCJFKTUAX-HUYCHCPVSA-N;

CAS number : 765922-62-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 765922-62-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Vizamyl;

Chemical formula : C14H11FN2OS;

Details

Origin ID

C90938;

UMLS CUI

C2983948;

Automatic exact mappings (from CISMeF team)
- flutemetamol [MeSH Supplementary Concept]
CISMeF manual mappings
- (18F)flutemetamol [International Nonproprietary Name]
Currated CISMeF NLP mapping
- (18F)flutemetamol [MeSH concept]
- Flutemetamol (18-F) (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing flutemetamol (18-F) (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- (18F)flutemetamol [MeSH concept]
- (18F)flutemetamol [International Nonproprietary Name]
- Flutemetamol (18-F) (substance) [SNOMED CT concept]
- Product containing flutemetamol (18-F) (medicinal product) [SNOMED CT concept]
- flutemetamol (18F) [ATC Code]
Validated automatic mappings to BTNT
- flutemetamol (18F) [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Amyloid-Beta Precursor Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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