Oxidative Stress

Preferred Label : Oxidative Stress;

NCIt definition : A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or normal aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer's, and many others.;

Alternative definition : NCI-GLOSS: A condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.;

Codes from synonyms : CDR0000044072;

Details

Origin ID

C17741;

UMLS CUI

C0242606;

Automatic exact mappings (from CISMeF team)
- Increased reactive oxygen species production [HPO term]
- Oxidative stress [MedDRA Preferred Term]
- oxidative stress [Artificial nutrition thesaurus concept]
Currated CISMeF NLP mapping
- oxidative stress [Disease (Nov.)]
- oxidative stress [MeSH Descriptor]
- oxidative stress [MeSH concept]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- Oxidative stress [MedDRA Preferred Term]
- oxidative stress [Disease (Nov.)]
- oxidative stress [MeSH concept]
- oxidative stress [MeSH Descriptor]
biological_process_has_initiator_chemical_or_drug
- Free Radical [NCIt concept]
biological_process_has_result_biological_process
- Cellular Stress Response [NCIt concept]
- DNA Repair [NCIt concept]
- Detoxification [NCIt concept]
biological_process_involves_gene_product
- Amyloid-Beta Precursor Protein [NCIt concept]
- Catalase [NCIt concept]
- Extracellular Superoxide Dismutase [Cu-Zn] [NCIt concept]
- Glutathione Peroxidase 1 [NCIt concept]
- Nuclear Factor Erythroid 2-Related Factor 2 [NCIt concept]
- Sulfiredoxin-1 [NCIt concept]
- Superoxide Dismutase [Cu-Zn] [NCIt concept]
- Superoxide Dismutase [Mn], Mitochondrial [NCIt concept]
process_involves_gene
- APP Gene [NCIt concept]
- APP wt Allele [NCIt concept]
- CAT Gene [NCIt concept]
- CAT wt Allele [NCIt concept]
- GPX1 Gene [NCIt concept]
- GPX1 wt Allele [NCIt concept]
- SOD1 Gene [NCIt concept]
- SOD1 wt Allele [NCIt concept]
- SOD2 Gene [NCIt concept]
- SOD2 wt Allele [NCIt concept]
- SOD3 Gene [NCIt concept]
- SOD3 wt Allele [NCIt concept]
- SRXN1 Gene [NCIt concept]
- SRXN1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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