GPX1 wt Allele

Preferred Label : GPX1 wt Allele;

NCIt synonyms : MGC14399; MGC88245; GSHPX1; Glutathione Peroxidase 1 wt Allele;

NCIt definition : Human GPX1 wild-type allele is located in the vicinity of 3p21.3 and is approximately 12 kb in length. This allele, which encodes glutathione peroxidase 1 protein, is involved in detoxification of hydrogen peroxide. Variant alleles of GPX1 are associated with type 2 diabetes mellitus as well as certain types of cancer such as breast, lung and prostate cancer.;

GenBank Accession Number : NM_000581;

Details

Origin ID

C55289;

UMLS CUI

C1880879;

OMIM relation
- Glutathione peroxidase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Type 2 Diabetes Mellitus [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 3p21.3 [NCIt concept]
gene_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Flumazenil Cardioprotection Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Oxidative Stress [NCIt concept]

Keyword's position in hierarchy(ies) :

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