Free Radical - CISMeF

Preferred Label : Free Radical;

NCIt synonyms : Free Radicals;

NCIt definition : Molecules or atoms with at least one unpaired or 'free' electron in the outermost electron shell. Chemically unstable, free radicals stabilize themselves by appropriating an electron from a nearby molecule, thereby damaging that molecule by altering the electron number in its outermost electron shell. By-products of both normal cell processes and environmental toxin exposure, oxygen free-radicals in high concentrations may damage DNA, proteins, and lipids, thereby increasing the risk for various diseases including cancer. (NCI04);

Alternative definition : NCI-GLOSS: A type of unstable molecule that is made during normal cell metabolism (chemical changes that take place in a cell). Free radicals can build up in cells and cause damage to other molecules, such as DNA, lipids, and proteins. This damage may increase the risk of cancer and other diseases.;

ChEBI ID : CHEBI:26519;

Codes from synonyms : CDR0000044030;

Details

Origin ID

C512;

UMLS CUI

C0016693;

Automatic exact mappings (from CISMeF team)
- free radical [Artificial nutrition thesaurus concept]
Semantic type(s)
- Inorganic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Free radical (substance) [SNOMED CT concept]
- free radical [IUPAC Term]
- free radical [SNOMED Notion]
- free radicals [MeSH concept]
- free radicals [MeSH Descriptor]
chemical_or_drug_initiates_biological_process
- Oxidative Stress [NCIt concept]

Keyword's position in hierarchy(ies) :

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