Integrin Signaling Pathway

Preferred Label : Integrin Signaling Pathway;

Alternative definition : BIOCARTA: Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals. Interactions between the extracellular matrix and the actin cytoskeleton commonly take place at focal adhesions on the cell surface that contain localized concentrations of integrins, signaling molecules, and cytoskeletal elements. Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and signaling factors. Paxillin and CAS also localize in focal adhesions and may serve as a scaffold for other integrin signaling components like FAK and src. Interaction of FAK, CAS and src may be required for integrin regulation of cell cycle progression. The CrkL adaptor protein may regulate downstream integrin signaling. Growth factor signaling pathways and the caveolin receptor exhibit important cross talk with integrin receptors in cellular responses like activation of map kinase, proliferation and motility. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_integrinPathway;

Details

Origin ID

C39131;

UMLS CUI

C1512812;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Adapter Molecule crk [NCIt concept]
- Breakpoint Cluster Region Protein [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Calpain-1 Catalytic Subunit [NCIt concept]
- Caveolin-1 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Paxillin [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Retinoblastoma-Like Protein 2 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tyrosine-Protein Kinase CSK [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Vinculin [NCIt concept]
- Zyxin [NCIt concept]
pathway_has_gene_element
- BCAR1 wt Allele [NCIt concept]
- BCR wt Allele [NCIt concept]
- CAPN1 wt Allele [NCIt concept]
- CAV1 wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- CSK wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RAPGEF1 wt Allele [NCIt concept]
- RBL2 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]
- ZYX wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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