Retinoblastoma-Like Protein 2

Preferred Label : Retinoblastoma-Like Protein 2;

NCIt synonyms : Retinoblastoma-Like 2; PRB2; RBL2; RBR2; p130; 130 kDa Retinoblastoma-Associated Protein; Retinoblastoma-Like-2 Protein;

NCIt definition : Retinoblastoma-like protein 2 (1139 aa, 130 kDa) is encoded by the human RBL2 gene. This protein plays a role in the regulation of cell division.;

NCIt note : Expressed only in G0, retinoblastoma-like 2 protein binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2.;

Details

Origin ID

C29831;

UMLS CUI

C0249759;

OMIM relation
- Rb transcriptional corepressor-like 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RBL2 protein, human [MeSH Supplementary Concept]
- RBL2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- RBL2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_is_element_in_pathway
- CXCR4 Signaling Pathway [NCIt concept]
- Cell to Cell Adhesion Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
gene_product_is_physical_part_of
- DREAM Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients