Cell to Cell Adhesion Signaling Pathway

Preferred Label : Cell to Cell Adhesion Signaling Pathway;

NCIt related terms : Cell to Cell Adhesion Signaling;

Alternative definition : BIOCARTA: Interactions between cells, responsible for cell to cell adhesion, can communicate signals into the cellular interior. These signals often involve interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells, such as in formation of epithelial cell layers. E-cadherin inactivation has been implicated in cancer development. In addition to mediating adhesion with other cells, cadherins transduce signals into cells through interactions with the catenins. Catenins probably affect actin cytoskeletal function through interactions with proteins such as actinin and vinculin. Catenins also probably trigger changes in cell shape and motility by signals through the Rho small GTPases. Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation. Src phosphorylates PECAM-1 on tyrosine residues causing SHP-2 association with PECAM-1. Paxillin acts as an adaptor protein between proteins involved in adhesion signaling like FAK and src and cytoskeletal elements. In addition to signals created by adhesion molecules to alter cellular responses, other signaling pathways can alter adhesion through components of the focal adhesion complex. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cell2cellPathway;

Details

Origin ID

C39024;

UMLS CUI

C1516364;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Catenin Alpha-1 [NCIt concept]
- Catenin Alpha-2 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Paxillin [NCIt concept]
- Platelet Endothelial Cell Adhesion Molecule [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Retinoblastoma-Like Protein 2 [NCIt concept]
- Tyrosine-Protein Kinase CSK [NCIt concept]
- Vinculin [NCIt concept]
pathway_has_gene_element
- BCAR1 wt Allele [NCIt concept]
- CSK wt Allele [NCIt concept]
- CTNNA1 wt Allele [NCIt concept]
- CTNNA2 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- PECAM1 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RBL2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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