Vinculin - CISMeF

Preferred Label : Vinculin;

NCIt synonyms : VCL; Metavinculin; MV; Epididymis Luminal Protein 114;

NCIt definition : Vinculin (1134 aa, 124 kDa) is encoded by the human VCL gene. This protein plays a role in the modulation of both cell-matrix adhesion and cell-cell adhesion.;

NCIt note : Vinculin is phosphorylated on serines, threonines and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin. (OMIM, Swiss-Prot, LocusLink);

Details

Origin ID

C17430;

UMLS CUI

C1454484;

Currated CISMeF NLP mapping
- Vinculin [FMA entity]
- vinculin [MeSH Descriptor]
- vinculin [MeSH concept]
OMIM relation
- Vinculin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- VCL protein, human [MeSH concept]
- VCL protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
- VCL Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Myristic Acylation Site [NCIt concept]
- Palmitic Acylation Site [NCIt concept]
- Phosphorylation Site [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Cell to Cell Adhesion Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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