Pyk2 and Map Kinase Pathway

Preferred Label : Pyk2 and Map Kinase Pathway;

NCIt related terms : Links between Pyk2 and Map Kinases;

Alternative definition : BIOCARTA: This pathway is a compilation of Pyk2 effort cascades; in specific cell types the receptor and effectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2 signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatives the JNK cascade, starting with PAK followed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_pyk2Pathway;

Details

Origin ID

C39206;

UMLS CUI

C1514612;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Retinoblastoma-Like Protein 2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
pathway_has_gene_element
- BCAR1 wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- GNAQ wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RBL2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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