CXCR4 Signaling Pathway

Preferred Label : CXCR4 Signaling Pathway;

Alternative definition : BIOCARTA: CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to binding its ligand SDF-1 (stromal cell-derived factor-1), CXCR4 triggers the migration and recruitment of immune cells. This ligand-receptor pair may also play a role in development of the nervous system. In addition to acting as a chemokine receptor, CXCR4 is a co-receptor for entry of HIV into T cells and ligands of CXCR4, including SDF-1, may help to block HIV infection. Early in the infection of an individual, HIV viruses often are tropic for the CCR5 coreceptor that provides for macrophage entry, then later in infection are tropic for CXCR4 and T cell entry. Viruses that are tropic for CXCR4 are generally syncytium forming, causing T cells to aggregate and be destroyed at a rapid rate. CXCR4 induces downstream signaling by several different pathways. As a GPCR, CXCR4 binding of SDF-1 activates G-protein mediated signaling, including downstream pathways such as ras, and PI3 kinase. PI3 kinase activated by SDF-1 and CXCR4 plays a role in lymphocyte chemotaxis in response to these signals. One endpoint of CXCR4 signaling is the activation of transcription factors such as AP-1 and chemokine regulated genes. JAK/STAT signaling pathways also appear to play a role in SDF-1/CXCR4 signaling. Delineation of the signaling mechanisms utilized by CXCR4 may assist in determining the role of CXCR4 in HIV infection and in the immune response. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cxcr4Pathway;

Details

Origin ID

C39043;

UMLS CUI

C1511460;

Automatic exact mappings (from CISMeF team)
- C-X-C chemokine receptor CXCR4 signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- C-X-C chemokine receptor CXCR4 signaling pathway [GO term]
has_gene_product_element
- Adapter Molecule crk [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Retinoblastoma-Like Protein 2 [NCIt concept]
- Stromal Cell-Derived Factor 1 [NCIt concept]
pathway_has_gene_element
- BCAR1 wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CXCL12 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAQ wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PIK3C2G wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RBL2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients