" /> C-X-C Chemokine Receptor Type 4 - CISMeF





Preferred Label : C-X-C Chemokine Receptor Type 4;

NCIt synonyms : Neuropeptide Y Receptor Y3; Fusin; Seven-Transmembrane-Segment Receptor, Spleen; SDF-1 Receptor; Chemokine (C-X-C Motif) Receptor 4; Stromal Cell-Derived Factor 1 Receptor; LPS-Associated Protein 3; CXCR4 Receptor; Lipopolysaccharide-Associated Protein 3; SDF1/PBSF Receptor CXCR4; Leukocyte-Derived Seven Transmembrane Domain Receptor; CD184 Antigen; CXCR4; Chemokine, CXC Motif, Receptor 4; FB22; Leukocyte-Derived Seven-Transmembrane-Domain Receptor; CXC-R4; LAP-3; HM89; LESTR; LCR1; SDF1-PBSF Receptor-CXCR4; CXCR-4;

NCIt definition : C-X-C chemokine receptor type 4 (352 aa, 40 kDa) is encoded by the human CXCR4 gene. This protein is involved in the stimulation of mitogenic signaling pathways, vascularization of the gastrointestinal tract and hematopoiesis.;

NCIt note : CXCR4 shares features common to G protein coupled receptors. CXCR4 is a receptor for the CXC chemokine PBSF/SDF1 and functions as a co-receptor for HIV-1. CXCR4 is broadly expressed in the immune and the central nervous systems and can mediate migration of resting leukocytes and hematopoietic progenitors in response to SDF1. PBSF/SDF1 and CXCR4 define a signaling system for organ vascularization. (OMIM); C-X-C chemokine receptor type 4 acts as a coreceptor (with T-cell surface glycoprotein CD4 as the primary receptor) or as the primary receptor for certain strains of HIV.;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
30/04/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.