Calpain - CISMeF

Preferred Label : Calpain;

NCIt synonyms : Papain-Like Cysteine Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase;

NCIt definition : A class of calcium-dependent thiol-proteases that proteolytically cleave a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two main isoforms of the protein, which differ in their calcium requirement for activation. These enzymes have been linked to both acute and chronic neurodegenerative processes, such as: ischemia, trauma, and Alzheimer's disease.;

Details

Origin ID

C16377;

UMLS CUI

C0006784;

Biochemical function of gene products
- Calpain-1 Catalytic Subunit [NCIt concept]
- Calpain-2 Catalytic Subunit [NCIt concept]
- Calpain-3 [NCIt concept]
Currated CISMeF NLP mapping
- calpain [MeSH Descriptor]
- calpain [MeSH concept]
- calpain [SNOMED Notion]
False automatic mappings
- Calpain (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Calpain (substance) [SNOMED CT concept]
- calpain [MeSH concept]
- calpain [SNOMED Notion]
- calpain [MeSH Descriptor]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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