Calpain-2 Catalytic Subunit

Preferred Label : Calpain-2 Catalytic Subunit;

NCIt synonyms : CANP 2; EC 3.4.22.53; CAPN2; Calpain M-Type; Calpain Large Polypeptide L2; M-Calpain; Millimolar-Calpain; Calpain-2 Large Subunit; Calcium-Activated Neutral Proteinase 2;

NCIt definition : Calpain-2 catalytic subunit (700 aa, 80 kDa) is encoded by the human CAPN2 gene. This protein plays a role in calcium-dependent cysteine-type endopeptidase activity.;

Details

Origin ID

C188877;

UMLS CUI

C3490063;

Automatic exact mappings (from CISMeF team)
- Calpain 2 [OMIM gene]
- calpain complex [GO term]
- m-calpain [MeSH concept]
- m-calpain [MeSH Supplementary Concept]
OMIM relation
- Calpain 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CAPN2 protein, human [MeSH Supplementary Concept]
- CAPN2 protein, human [MeSH concept]
gene_encodes_gene_product
- CAPN2 Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Calpain [NCIt concept]
gene_product_has_structural_domain_or_motif
- EF-Hand Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway BioCarta [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytoskeletal Modeling [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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