Preferred Label : EF-Hand Domain;
NCIt synonyms : EF-Hand Motif; EF-Hand Calcium-Binding Motif; EF-Hand; EF Hand;
NCIt definition : Forming a single Ca2 -binding site in many calcium-binding proteins, the basic EF-Hand
Domain consists of a conserved 12-residue loop region between two perpendicular 10-12
residue alpha helices (helix-loop-helix). Ca2 interacts with loop residues in a pentagonal
bipyramidal configuration; each loop residue is important for Ca2 coordination. Loop
residues 1, 3, 5, 7, 9, and 12 (invariant Glu or Asp) are directly necessary for Ca2
binding. Amino-acid variations at positions 1, 3, 5, 7, and 9 alter ion affinity.
Single or multiple domains cause structural/functional variations. EF-hand Proteins
are grouped into either regulatory/signaling or structural/buffering/transport categories.
Ca2 binding to regulatory proteins induces conformational/functional change; Ca2
binding to structural proteins seems to provide a Ca2 buffer. (NCI);
Origin ID : C13956;
UMLS CUI : C0752218;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- is_structural_domain_or_motif_of_gene_product
