Reticulocalbin-2

Preferred Label : Reticulocalbin-2;

NCIt synonyms : Endoplasmic Reticulum Calcium-Binding Protein 55kD; RCN2; E6-Binding Protein; Calcium-Binding Protein ERC55; E6BP; Reticulocalbin 2;

NCIt definition : Reticulocalbin-2 (317 aa, 37 kDa) is encoded by the human RCN2 gene. This protein is involved in calcium binding.;

NCIt note : Reticulocalbin-2 contains 6 conserved helix-loop-helix EF-hand calcium-binding domains and a C-terminal HDEL sequence, which is required for ER retention.; Reticulocalbin-2 appears to interact with human papillomavirus transforming protein E6 and with the vitamin D receptor. (OMIM);

Details

Origin ID

C29835;

UMLS CUI

C1335763;

OMIM relation
- Reticulocalbin 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RCN2 protein, human [MeSH Supplementary Concept]
- RCN2 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- RCN2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Calcium-Binding Domain [NCIt concept]
- EF-Hand Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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