Preferred Label : Calcium-Binding Domain;
NCIt synonyms : Calcium-Binding Motif;
NCIt definition : Many calcium-binding proteins belong to the same evolutionary family and share a type
of calcium-binding domain known as the EF-hand. This type of domain consists of a
twelve residue loop flanked on both side by a twelve residue alpha-helical domain.
In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration.
The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these
residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position
12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048);
Origin ID : C14114;
UMLS CUI : C1516143;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
