Diacylglycerol Kinase Alpha

Preferred Label : Diacylglycerol Kinase Alpha;

NCIt synonyms : 80 kDa Diacylglycerol Kinase; DAG Kinase Alpha; Diglyceride Kinase Alpha; Diacylglycerol Kinase, Alpha; EC 2.7.1.107; DGKA;

NCIt definition : Diacylglycerol kinase alpha (735 aa, 83 kDa) is encoded by the human DGKA gene. This protein is involved in the negative regulation of second messenger signaling through lipid phosphorylation.;

Details

Origin ID

C112503;

UMLS CUI

C3815868;

Automatic exact mappings (from CISMeF team)
- Diacylglycerol kinase, alpha, 80-kd [OMIM gene]
- diacylglycerol kinase alpha [HGNC gene]
OMIM relation
- Diacylglycerol kinase, alpha, 80-kd [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- DGKA Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Lymphocyte [NCIt concept]
- Oligodendrocyte [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- EF-Hand Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Glycerolipid Metabolism Pathway [NCIt concept]
- Glycerophospholipid Metabolism Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- DGK-alpha Inhibitor GS-9911 [NCIt concept]
- DGKalpha Inhibitor BAY 2862789 [NCIt concept]

Keyword's position in hierarchy(ies) :

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