Preferred Label : DAG/PE-Binding Domain;
NCIt synonyms : Diacylglycerol Binding Domain; DAG Binding Domain; Phorbol Ester Binding Domain; Protein Kinase C Conserved Region 1 Domain; C1 Domain; DAG PE-Binding Domain;
NCIt definition : The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain
of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second
messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about
50 amino-acid residues long; the domain binds two zinc ions, probably involving the
conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment
of proteins to the membrane via basic residues that interact with lipid head groups.
Part of the domain contains two beta sheets that form a cavity and a short C-terminal
alpha helix; another contains two zinc-binding sites that maintain the domain fold.
Binding of diacylglycerol, or phorbol ester, to the domain results in modification
of protein function. (NCI);
Origin ID : C14080;
UMLS CUI : C1511644;
- Semantic type(s)
- is_structural_domain_or_motif_of_gene_product