Kinase Suppressor of Ras 2

Preferred Label : Kinase Suppressor of Ras 2;

NCIt synonyms : hKSR2; EC 2.7.11.1;

NCIt definition : Kinase suppressor of Ras 2 (950 aa, 108 kDa) is encoded by the human KSR2 gene. This protein plays a role in both the localization and sequestration of mitogen-activated protein kinase kinase family members.;

NCIt note : The kinase suppressor of Ras 2 protein kinase domain is predicted to be catalytically inactive. However, this protein has a low level of intrinsic kinase activity, which is increased following interactions with BRAF. (UniProt);

Details

Origin ID

C97222;

UMLS CUI

C3180621;

OMIM relation
- Kinase suppressor of ras 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KSR2 protein, human [MeSH Supplementary Concept]
- KSR2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- KSR2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Renal Tissue [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Scaffolding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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