Guanine Nucleotide Exchange Factor VAV3

Preferred Label : Guanine Nucleotide Exchange Factor VAV3;

NCIt synonyms : VAV3; Vav 3 Guanine Nucleotide Exchange Factor; Protein Vav-3; VAV3 Protein; VAV-3;

NCIt definition : Guanine nucleotide exchange factor VAV3 (847 aa, 98 kDa) is encoded by the human VAV3 gene. This protein plays a role in guanine nucleotide exchange for transforming protein RhoA, Rho-related GTP-binding protein RhoG, and Ras-related C3 botulinum toxin substrate 1.;

Details

Origin ID

C21444;

UMLS CUI

C0904737;

OMIM relation
- Vav guanine nucleotide exchange factor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- VAV3 protein, human [MeSH concept]
- VAV3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Signaling Pathway Gene [NCIt concept]
- VAV3 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Lymphocyte [NCIt concept]
- Placenta [NCIt concept]
- Spleen [NCIt concept]
- Thymus Gland [NCIt concept]
gene_product_has_structural_domain_or_motif
- Acidic Region [NCIt concept]
- DAG/PE-Binding Domain [NCIt concept]
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Ephrin A Forward Signaling Pathway [NCIt concept]
- Ephrin A2 Forward Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytoskeletal Modeling [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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